Transanal total mesorectal excision compared to laparoscopic TME for mid and low rectal cancer—current evidence
Original Article

Transanal total mesorectal excision compared to laparoscopic TME for mid and low rectal cancer—current evidence

Stefan E. van Oostendorp1, Thomas W. A. Koedam1, Colin Sietses2, H. Jaap Bonjer1, Jurriaan B. Tuynman1

1Department of Surgery, VU University Medical Centre, Amsterdam, The Netherlands; 2Department of Surgery, Gelderse Vallei Hospital, Ede, The Netherlands

Contributions: (I) Conception and design: JB Tuynman; (II) Administrative support: None; (III) Provision of study materials or patients: None; (IV) Collection and assembly of data: SE van Oostendorp; (V) Data analysis and interpretation: SE van Oostendorp, JB Tuynman; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

Correspondence to: Stefan E. van Oostendorp. Department of Surgery, VU University Medical Centre, De Boelelaan 1117, Postbus 7057, 1007 MB, Amsterdam, The Netherlands. Email:

Background: Transanal total mesorectal excision (TaTME) is potentially the answer to refractory challenges in rectal cancer surgery. The surgical dissection in the deep pelvis is facilitated by a down to up approach with modern laparoscopic techniques. Potential benefits are decrease in short-term morbidity including anastomotic leakages, in conversion and colostomy rate, and better quality of specimens including less R1 rates. Long-term oncological outcome data is lacking and needs to be reviewed thoroughly. Initial (comparative) series show promising results, however there is a lack of audited data and comparative data between laparoscopic TME (LaTME) and TaTME. This review compares available data of LaTME and TaTME.

Methods: A systematic review was performed in PubMed to identify papers reporting TaTME series with minimal 15 patients. A comparative set of recent large RCT data on LaTME was constructed. Weighted averages were derived from the extracted data. Primary endpoints were short-term morbidity, anastomotic leakage, conversion, pathological outcomes and local recurrences (LR).

Results: The search yielded 1,093 papers, of which after the selection process resulted in the inclusion of 23 series on TaTME. To make a comparison, the four latest RCT’s on LaTME were identified as a referential group. The international TaTME registry paper was presented separately to make a third comparative group. Average morbidity 31.5% and 39.6% and anastomotic leakage 6.9% vs. 8.0% both in favor of TaTME. Conversion rate was 2.0% vs. 15.7% for TaTME and LaTME respectively. Complete mesorectal integrity 86.2% vs. 81.5% and CRM+ 4.6% vs. 7.9%. Five urethral injuries (0.7%) were reported. Long-term outcomes of LRs were reported in a minority of studies with heterogeneous follow-up intervals.

Conclusions: This review summarizes the data and potential benefits of TaTME. Compared to LaTME, TaTME decreases short-term morbidity, conversion, suboptimal quality of the specimen and involved CRM rate. Due to concerns about underreporting of poor outcomes, a well-designed randomized controlled trial with quality assurance and report on oncological safety is needed before widespread implementation can be justified.

Keywords: Transanal total mesorectal excision (TaTME); NOTES TME; review

Received: 20 February 2018; Accepted: 28 March 2018; Published: 10 May 2018.

doi: 10.21037/ales.2018.04.02


Transanal total mesorectal excision (TaTME) is the potential answer to refractory challenges in the surgical resection of mid and low rectal cancer. Since the first reports of this approach by its pioneers in 2010, the technique has gained wide attention in the surgical community (1,2). The technique facilitates dissection of the very distal rectum and mesorectum providing excellent view of the anatomy in the deep pelvis. Especially difficult cases (e.g., obese, male patients with bulky distal tumors) seem to benefit from the transanal approach. Nevertheless, no randomized evidence is present to support any benefits. Also, in systematic reviews as well as reported in registries the benefits of TaTME compared to LaTME seem modest and long-term oncological outcome is awaited (3-5). Current problems in TME surgery are short-term morbidity including anastomotic leakage, conversions to open surgery in 10–25%, unintended end colostomies, poor specimen quality, circumferential resection margin (CRM) involvement, distal margins rates and local recurrences (LR).

Laparoscopic TME (LaTME) surgery is associated with substantial short-term morbidity of 30–40%. This includes anastomotic leakage rates around 8% (6,7). The conversion rate in LaTME is still above 10% as reported in recent trials and even with robotic surgery this percentage remains between 10% and 20%, especially in obese patients (8-11). Conversion to open surgery occurs due to difficult dissection and is associated with higher morbidity and worse oncological outcome (12-15).

Currently an increase focus is seen towards sphincter preserving therapy (16,17). The open intersphincteric resection and transanal dissection creates the possibility of saving the sphincter avoiding end colostomies, but LaTME still results in a relatively high rate of APR, which has negative impact on quality of life. Transanal minimal invasive access with high-quality images creates the potential to achieve a higher rate of sphincter saving procedures. Nevertheless, data regarding unintended AP resections are scarce and only within a randomized comparison it will be possible to evaluate this aspect. High-quality surgery with respect to the embryological avascular planes aims to achieve an intact mesorectal envelope and offers good local control, especially with neoadjuvant radiotherapy if indicated (18,19). An involved CRM remains a concern since this is a substantial risk factor for LRs. Laparoscopic surgery with an intent for TME result in an involved CRM of 17% as is shown in national registries (20). Potentially the mesorectum is not totally removed in TME surgery as shown by the presence of residual mesorectum in 40% upon evaluation by MRI 6 months after surgery in 46.9% (21).

The TaTME technique could improve outcomes for patients with mid and low rectal cancer overcoming the limitations of dissection the angulated rectum deep within the pelvis (1,12). Especially the known difficult LaTME resection will probably benefit from the TaTME approach such as male sex, low tumor, high body mass index (BMI) and bulky or anteriorly situated tumours (22). In these situations, deep mesorectal dissection, safe resection margins (both distal and circumferential) and safe stapled transection, without the need for multiple firings, may not be achieved requiring conversion to open surgery (12,20). Furthermore, in (ultra)low anterior resections for tumours situated close to but not grown into the pelvic floor, the rate of end-colostomy (APR) for technical considerations outstands the rate in which it is an oncological necessity (16). TaTME may overcome these challenges by improved visualization and ergonomics. By enabling a more precise distal dissection in the embryological planes, theoretically the autonomic nerves can be preserved possibly leading to improved functional outcomes (23,24).

In this review we focus to current evidence of laparoscopic rectal surgery and TaTME with respect to morbidity including anastomotic leakage, conversion, colostomy, involved resection margins and LRs.


We performed a PubMed search with a similar syntax as recently published to identify studies, published since January 2005, reporting on outcomes of TaTME (4). The final search was performed at 25 January 2018 with the following syntax:

((((excision*[tiab] OR resection*[tiab] OR TME[tiab] OR TaTME[tiab] OR TAMIS[tiab] OR NOTES[tiab] OR proctectom*[tiab]) AND (transanal*[tiab] OR trans-anal*[tiab])) OR ((excision*[ot] OR resection*[ot] OR TME[ot] OR TaTME[ot] OR TAMIS[ot] OR NOTES[ot] OR proctectom*[ot]) AND (transanal*[ot] OR trans-anal*[ot]))) AND (((("Neoplasms"[Mesh] OR neoplas*[tw] OR tumor*[tw] OR tumour*[tw] OR cancer*[tw] OR malignan*[tw] OR oncolog*[tw] OR carcinom*[tw] OR adenocarcinom*[tw]) AND ("Rectum"[Mesh] OR rectum[tiab] OR rectal[tiab] OR colorect*[tiab] OR mesorect*[tiab])) AND ("surgery"[Subheading] OR surgery[tiab] OR surgical[tiab] OR operati*[tiab])) OR (“Rectal Neoplasms/surgery”[Mesh:noexp]))).

For this paper, case-series, cohorts and comparative studies, with a minimum of 15 patients that underwent Transanal TME for rectal cancer were included. The transanal approach had to be an endoscopic technique, therefore papers on open transanal approach (TaTa) were excluded. Moreover, animal and cadaver studies were not included. Language in which the cohorts were reported was restricted languages with the Latin alphabet.

The international registry of TaTME was isolated from the other retrieved series on TaTME, because of its different design and the rather large proportion of indications other that rectal cancer such as IBD, completion proctectomy and Hartmann reversal (25).

In addition, to provide the most recent evidence from randomized clinical trials regarding LaTME, data from the laparoscopic arms of large, n≥200, multi-center RCT’s published after 01-01-2015 were isolated and recorded.

Primary endpoints were type of surgery, morbidity, anastomotic leakage, defined as (partial) dehiscence, intraoperative complication as urethral injury, intraoperative bleeding, stoma-rate, conversion, clinicopathological parameters as quality of the mesorectum, CRM and distal margin involvement and long-term oncological outcome as LRs.

Statistical analysis

Because a minority reported comparative data on TaTME and LaTME, no direct comparative meta-analysis could be performed. Instead, for the retrieved laparoscopic and TaTME studies, a separate weighted average was provided for the retrieved baseline characteristics and outcomes. The calculated weighted percentages and crude data (events and adjusted total population per outcome) of the LaTME and retrieved TaTME series, as well as the TaTME registry are presented in tables.

For the primary endpoints, if possible, a separate weighted average of the proportions was determined by means of the generic inverse-variance method. This is a method for aggregating multiple effect sizes to minimize the variance of the weighted average, giving more weight to the effect of large studies than to small ones. Analyses were performed with the inverse-variance method, using a random-effects model. Heterogeneity was assessed by use of the I2 statistic. The software used for statistical analysis was R version 3.2.2 (R Foundation for Statistical Computing, Vienna, Austria).


The PubMed search on TaTME resulted in 1,093 papers. Selection by title/abstract excluded 1,058 studies which resulted in 35 papers for full text analysis. Of those, nine papers were excluded for N≤15 (26-34). Other reasons of exclusion were the use of another technique or non-availability of full-text for two other articles (35,36). Eventually, 24 papers on TaTME were included in this paper, of which overlap existed by 2 papers from the same clinic (37,38). Since the latter paper focused on pathological outcomes, from this paper only the pathological data were extracted; quality of mesorectum, CRM and DRM positivity (38). Because of its unique design the TaTME registry was not pooled with the other series in the meta-analysis (25). See Figure 1 flowchart and Table S1 search results.

Figure 1 Flow-chart of TaTME search. Meta-analysis of the single proportions by inverse variance with a random effects model. Proportions are shown with 95% CI. From: Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA Statement. PLoS Med 2009;6:e10000097. TaTME, transanal total mesorectal excision.
Table S1
Table S1 Search results 25-01-2018
Full table

The selection of the open/robotic versus LaTME multicenter RCT’s with an arm of N≥200 resulted in the ROLARR, COLOR II, ALaCaRT and ACOSOG Z6051 (8,9,39-41).

TaTME series and registry

The 23 included TaTME cohorts varied in design and inclusion criteria and reported clinical and pathological outcomes of 1,107 patients, online: TaTME (37,38,42-62). Fourteen single center series (37,43-47,51,53-55,57-60), of which one published 2 papers (37,38), 7 dual or multicenter (42,48,50,53,56,61,62) and one paper of an implementation pathway (49) were included. One of the single center papers included solely advanced or recurrent low rectal cancers (59). Furthermore, for the pathological data of the largest single center experience, Hospital Clinic, we extracted the data of their latest paper on pathological endpoints (38). The indication for TaTME was merely rectal cancer varying from <5 to 15 centimeter from the anal verge, however some included a few benign cases. Due to heterogeneous inclusion criteria regarding intent for continuity; pooling for APR or LAR rate could not be performed (Table 1). Baseline characteristics, Surgical and postoperative outcomes of the TaTME series can be found in online: TaTME.

Table 1
Table 1 Weighted averages
Full table

The TaTME registry encompasses 1,594 patients who received an anastomosis after TaTME, of which 1,540 procedures were for rectal cancer, and in the appendix an additional 161 abdominoperineal resections (APR) were reported (25).


The LaTME arms of the before mentioned RCT’s covered short-term and pathological outcomes of 1,411 patients (8,9,39-41). Only the COLOR II trial reported the long-term outcomes: 5% LRs after 3 years (39). Patient demographics were comparable, but Fleshman et al. reported an neo-adjuvant therapy rate of 98% which was rather high compared with the 46–59% rate reported by the other trials, see Table S2 LaTME (41).

Table S2
Table S2 LaTME
Full table

The 4 studies reported an APR percentage of 11–29%, and had a weighted colostomy rate of 27% (Table 1). Conversion to open surgery was done in 13.7% and LaTME resulted in 8% anastomotic leakage. The retrieved crude data can be found in Table S2 LaTME.

Short-term morbidity and anastomotic leakage

The reported short-term morbidity (30-day) of the retrieved TaTME series varies between 8.7% and 52% with a weighted average of 31.5% versus an average of 39.6% short-term morbidity in laparoscopy (Table 1). In the meta-analysis of short-term morbidity, an average rate of 0.32 (95% CI, 0.28–0.36, I2=25.8%) of TaTME versus 0.39 (95% CI, 0.33–0.46, I2=80.6%) laparoscopy was calculated, but with serious risk at heterogeneity for LaTME. See Figure 2A,B.

Figure 2 Meta-analysis of the single proportions by inverse variance with a random effects model. Proportions are shown with 95% CI. (A) TaTME morbidity; (B) LaTME morbidity. TaTME, transanal total mesorectal excision; LaTME, laparoscopic TME.

The incidence of anastomotic leakage, defined as (partial dehiscence) was more or less equal for weighted average of laparoscopic (8.0%), TaTME (6.9%) and the Registry (7.8%) (Table 1). Interestingly, anastomotic failure, including pelvic abscess, fistula and sinus reached 15.8% if the 30-day was extended to 3 months (25). The meta-analysis of the weighted average of the proportions can be found in Figure 3A,B.

Figure 3 Meta-analysis of the single proportions by inverse variance with a random effects model. Proportions are shown with 95% CI. (A) TaTME leakage; (B) LaTME leakage. TaTME, transanal total mesorectal excision; LaTME, laparoscopic TME.

For TaTME specific intraoperative complications such as pelvic (sidewall or prescaral) bleeding and urethral injury, 10 (1.7%) and 5 (0.7%) cases were reported. The international TaTME registry report 4.2% intraoperative bleeding and 0.8% (n=12) urethral injuries (Table 1). The 30.6% intraoperative complication rate included technical aspects, such as difficulties with the transanal platform (25).


Conversion to open surgery is encountered less frequently in TaTME, 2.0% versus 13.7%. The registry reports an intermediate conversion rate of 5.6% (Table 1). Meta-analysis by inverse variance with a random effects model resulted in a 0.03 (95% CI, 0.02–0.05) rate of conversion in TaTME with low risk of heterogeneity (I2=0%), see Figure 4A. In LaTME this was 0.13 (95% CI, 0.09–0.16, I2=69.6%) with risk of heterogeneity, see Figure 4B.

Figure 4 Meta-analysis of the single proportions by inverse variance with a random effects model. Proportions are shown with 95% CI. (A) TaTME conversion; (B) LaTME conversion. TaTME, transanal total mesorectal excision; LaTME, laparoscopic TME.


The four RCT’s of LaTME encompassed an average of 20% APR for TME surgery, with a definitive stoma rate of 27% (Tables 1,S2). The retrieved TME series varied in inclusion criteria for APR’s, intersphincteric TME and low anterior resections. Therefore, an average APR-rate could not be calculated, but the reported definitive stoma rate was 7.6%. The registry paper focused on anastomotic leakage and excluded APR’s. However, the supplement stated 161 registered APR’s leading to a 12% definitive stoma rate in which also total proctocolectomies or completion proctectomies for benign indications were included (25).


The integrity of the mesorectum, defined by Quirke, was complete in 81.5% in laparoscopy and 86.2% in TaTME (Table 1). Distal resection margin positivity was 1.0% and 0.7% for LaTME and TaTME respectively. The weighted rate of a positive CRM, was 7.9% versus 4.6% in the LaTME and TaTME groups respectively (Table 1). For the pathological outcomes of the latest paper from the group of Lacy et al. was used (38).

Meta-analysis of complete mesorectum and CRM+ for both approaches are shown in Figure 5A,B and Figure 6A,B. The percentage of complete is 86% vs. 80% in the transanal versus pure laparoscopic approach, but with a high I2 of 90.8% in LaTME. The weighted average of the proportions shows a positive CRM of 0.08 (95% CI, of laparoscopic 0.06–0.11, I2=58%) in laparoscopy compared to 0.06 in TaTME (95% CI, 0.04–0.07, I2=0).

Figure 5 Meta-analysis of the single proportions by inverse variance with a random effects model. Proportions are shown with 95% CI. (A) TaTME mesorectum complete; (B) LaTME mesorectum complete. TaTME, transanal total mesorectal excision; LaTME, laparoscopic TME.
Figure 6 Meta-analysis of the single proportions by inverse variance with a random effects model. Proportions are shown with 95% CI. (A) TaTME CRM+; (B) LaTME CRM+. TaTME, transanal total mesorectal excision; LaTME, laparoscopic TME.


LR rate was reported 5% the 3-year follow-up paper in COLOR II-trial (39). None of the other LaTME trials reported 3-year follow-up yet. Neither the TaTME papers reported 3 years follow-up with LR percentages. However, an incidence of 17 LRs was reported, but (37,46,51,59,61,62). Of these 17 LRs, 5 were reported by Rouanet et al. who included locally advanced rectal cancer or LRs in his TaTME-series (59).


This is the latest systematic review of all the cohorts larger than 15 patients, describing the short-term results of TaTME. Because the comparison with LaTME is most important in evaluating the potential benefits of TaTME and comparative prospective clinical trial are still lacking we have added the result of the 4 latest randomized trials evaluating LaTME. TaTME compared to LaTME is beneficial in terms of conversion rate and clinico-pathological outcomes, morbidity and anastomotic leakage seems comparable. End colostomy (APR) rate and LRs could was not reliably reported by the retrieved studies, due to design and lack of long-term follow-up (37,38,42-62). Before widespread implementation can be justified, careful evaluation is warranted because morbidity has not decreased, and the rate of LR is still a concern and needs thorough evaluation in an RCT with quality control of surgery and data (63).

The short-term overall morbidity in TaTME was 31.5% which is beneficial compared to the registry data of 34.8% and pooled LaTME of 39.6%. This 31.5% rate of the TaTME cohorts must be interpreted with caution since morbidity was not reported in a standardized way such as the Clavien-Dindo classification. A concern in (laparoscopic) rectal cancer surgery remains anastomotic leakage which was 8% in the latest laparoscopic RCT data. It was imposed that leakage could be decreased by TaTME as a consequence of a new way of making an anastomosis without the need for cross stapling leaving dog-ears which are prone to ischemia (25,64). However, the current data do not suggest a decrease with a reported 30-day leak rate 7%. The open rectal stump which results after the dissection needs to be fused with the descending colon to create the anastomosis. This can be performed either by a hand sewn colo-anal anastomosis for very low anastomosis or by a stapled colo-rectal anastomosis with a circular stapling technique with the aid of a second purse string to close up the open rectal stump, which is described in detail in the 2016 paper in Techniques of coloproctology (64). TaTME potentially leads to more bacterial load as showed by Velthuis et al. and needs further investigation of the rate of anastomotic failure or pelvic abscess (65). The registry reported an anastomotic failure rate of 15.7% when late complications of the anastomosis such as fistula, chronic abscess or presacral sinuses were included (25). These numbers are comparable to the anastomotic leak rate, defined as not only early dehiscence but include presacral abscess or sinus, which builds up to 20% beyond the 30-day cut-off (6).

This paper shows a promising conversion rate of 2% in TaTME in the cohort series compared to 5.6% in the TaTME registry compared to 12.2–16.6% for LaTME as reported in the ROLARR and laparoscopic arms of the COLOR II, ALaCaRT and ACSOG-Z6501 trials (8,9,40,41). The main reasons for conversion to open surgery are extensive adhesions, intra-operative complications such as major bleeding, the inability to make progress in sharp dissection of the mesorectal envelope or to achieve a clear distal margin below the tumor (12). Risk-factors that contribute to difficulty are male sex, high BMI, visceral obesity, narrow pelvis, bulky tumours or more advanced stage of the tumours and these patients might be candidates for a down to up approach of mesorectal excision (10,11,66).

The average 20% APR-rate in LaTME surgery for rectal cancer as stated before impacts quality of life. This extensive procedure with resection of the sphincter complex is not always required from oncological point of view, which is mostly the risk of CRM+ due to ingrowth in the sphincter complex or levator ani, but is also performed for technical reasons such as the inability to get a satisfactory distal margin intraoperatively (16). Definitive colostomy-rate is even higher, adding some sphincter sparing Hartmann procedures without restoration of bowel continuity. TaTME enables lower sphincter saving, or intersphincteric, dissections with a colo-anal anastomosis in selected cases (16). Unintended APR rate resulting in end colostomy was an endpoint which could not be evaluated. The RCT series did not report the incidence of planned versus unplanned; one study reported an end colostomy rate of 79.7% in LaTME for the low rectum (0–5 cm from the AV) (9).

The CRM positivity, an important predictor of LR, was found to be less frequently involved in TaTME (67). This can be contributed by improved visualization of the surgical plane and improved ergonomics in the dissection of especially the lower (meso)rectum (1,2).

The integrity of the mesorectal envelope surrogates surgical quality by pursuing a smooth specimen which is correlated to LR (68). This review shows that TaTME results in better mesorectal integrity for TaTME as shown in Table 1. Positive distal resection margins are rarely encountered since the tumor can be directly visualized by the transanal endoscopic view (4). Furthermore, in case of a stapled anastomosis, the donuts of the EEA-31 hemorrhoid stapler add an extra 16 mm margin in addition to the original specimen (64). LRs are not well reported in the TaTME cohorts. Overall, 17 LRs were reported with a varying follow-up (9.7–29.0 months). The registry has not reported long-term oncological outcome and will probably underreport this fact because of the voluntary non-audited design. The trial data of LaTME reports a 5% LR rate at 3-year follow-up (39).

The lack of long-term outcome underlines the importance of a prospective trial with quality assurance and with auditing of the long-term data. Potentially tumor spill due to inadequate closure of the rectum or due to seeding due to manipulation could be a concern of the TaTME technique.

The cohorts and registry contain unaudited data and publication bias, therefore concern has risen about unreported poor outcomes. Urethral injuries have been mentioned at symposia and training sessions frequently, but fail to be equivalently reported in manuscripts (4,25,69). Other potential injuries such as side wall injury with the risk at major haemorrhage or autonomous nerve injury and a too low stapled anastomosis resulting in poor outcomes are also concerns especially in the learning curve. These potential disastrous complications warrant restraint of wide-spread rigorous implementation of the technique without proper training and auditing (22,70,71).

Although this review contains the most up-to-date overview of the available data substantial limitations are present which precludes any conclusion about the value of TaTME. Only cohort data with selection bias, publication bias and lack of audit. The registry data contains similar bias since data is missing and no audit of the data is present. Comparing RCT with cohort data is only presented due to lack of other comparative data and only serves as an indication. RCT’s often have better results compared to registries since the learning curve is less an issue whereas the TaTME data is biased by a learning curve which has shown to be associated with increased morbidity and worse specimens. The learning curve of laparoscopy has been set at 50–60 patients previous decade, measured by conversion and morbidity (72,73). Koedam et al. analyzed the individual learning curve of a surgeon starting TaTME, and concluded is achieved after 40 cases and 60 more are required to get to the level competent to teach others (Koedam et al. Tech coloproctology 2018, Accepted).

To shorten this learning curve, a training pathway has been designed which covers e-learning, live surgery, hands on cadaver course and on-site proctoring (32,70,71). The international TaTME consensus meeting on the design of a training-pathway concluded due to the technical demanding aspect of TaTME this approach should be reserved for dedicated colorectal surgeons who have extensive experience in both laparoscopic colorectal surgery and TAMIS for local excision (70). The results of the Australian & New Zealand training and implementation program that were included in this review reported the outcomes of 12 surgeons that performed 108 cases TaTME for rectal cancer with a 5.4% anastomotic leak rate, 1.9% CRM+, 0% DRM+ and an intact TME specimen in 107 cases (98.2%) suggesting high quality surgery (49).

Another need is quality assurance to ensure proficiency and safety and avoid patients and results of trials to be hampered by suboptimal performance of not sufficiently trained surgeons (74,75). A well designed trial with these components, in order to capture the real advantage and potential harms of a technique within a training pathway and a patient safety environment, avoids underreporting of poor outcomes and a randomized trial is best suited to rule out bias of excellence centers.

It is well recognized that randomization often discourages patients and surgeons which are in favor of one technique but no other trial design yet has been able to reproduce the level of evidence an adequately powered and executed RCT provides (76).


Continuous cohort reports on TaTME indicate a benefit in conversion rate compared to LaTME and potential increase in sphincter preservation. However, morbidity including anastomotic leakage and by this novel approach introduced specific complications as urethral or pelvic side-wall injury need prospective audit. A significant learning curve is present in the implementation and hampers fair comparison. Long-term oncological outcome does not seem to improve so far but randomized controlled trial with proper quality assurance is best suited to provide data on short-term outcomes as well long-term oncological safety.

The following URL shows supplementary data from the TaTME series:




Conflicts of Interest: The authors have no conflicts of interest to declare.


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doi: 10.21037/ales.2018.04.02
Cite this article as: van Oostendorp SE, Koedam TW, Sietses C, Bonjer HJ, Tuynman JB. Transanal total mesorectal excision compared to laparoscopic TME for mid and low rectal cancer—current evidence. Ann Laparosc Endosc Surg 2018;3:41.